Adult Max treatment duration: 28 days. Nosocomial pneumonia, community acquired pneumonia, complicated skin & soft tissue infections 600 mg IV over 30-120 min bid for 10-14 days.
Myelosuppression. Close monitoring of blood counts in patients w/ pre-existing anaemia, granulocytopenia or thrombocytopenia; are receiving concomitant medications that may decrease Hb levels, depress blood counts or adversely affect platelet count or function; have severe renal insufficiency; receive more than 10-14 days of therapy. Close monitoring of Hb levels, blood counts & platelet counts wkly is recommended during therapy. Antibiotic-associated diarrhoea & colitis including pseudomembranous colitis & C. difficile-associated diarrhoea; discontinue & adequate therapeutic measures should be initiated immediately if it occurs. Drugs inhibiting peristalsis. Lactic acidosis; mitochondrial dysfunction. Serotonin syndrome may occur if co-administered w/ serotonergic agents, including antidepressants eg, SSRIs. Peripheral or optic neuropathy. Currently taking or who have recently taken anti-TB medications. History of seizures or risk factors for seizures. Concomitant use w/ MAOIs is not recommended. Use w/ tyramine-rich foods. Superinfection. Patients w/ DM or other conditions associated w/ glucose intolerance; on controlled Na diet. Potential influence on ability to drive & use machines; do not drive or operate machinery if dizziness or symptoms of visual impairment occurs. Severe renal & hepatic impairment. Fertility impairment. Pregnancy. Discontinue breastfeeding during treatment. Not recommended in childn & adolescents <18 yr.
Candidiasis, oral/vag candidiasis, fungal infections; anemia; insomnia; headache, taste perversion, dizziness; HTN; diarrhoea, nausea, vomiting, localised or general abdominal pain, constipation, dyspepsia; abnormal LFT, increased AST, ALT or alkaline phosphatase; pruritus, rash; increased BUN; fever, localised pain; increased LDH, creatine kinase, lipase, amylase or non-fasting glucose, decreased total protein, albumin, Na or Ca, increased or decreased K or bicarbonate, increased neutrophils or eosinophils, decreased Hb, haematocrit or RBC count, increased or decreased platelet or WBC counts.
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